Cambodia, Lao PDR, Myanmar, and Vietnam, collectively known as CLMV, account for a third of ASEAN geographical area and experience continuous growth in both GDP and population. Despite relatively less developed infrastructure, these countries are gearing up for improving crop productivity and modernizing agriculture sector. This paper examines the agriculture sector as well as the macro trend in CLMV countries, reveals growth opportunities for crop science companies, and recommends strategies to seize the market potential.